Friday, May 7, 2010

Non-small Cell Lung Cancer (NSCLC) Prognosis

Non-small cell lung cancer prognosis depend on the following:
  • Lung Cancer Stage
    The size of the tumor and whether the tumor has spread (metastasis) or no.
  • Lung Cancer symptoms
    such as coughing or trouble breathing.
  • Patient health
    The treatment for lung cancer cannot done if the patient health is not in good condition.

However, there are also another factor that may influence the lung cancer prognosis these included sex; serum LDH and albumin; haemoglobin, white cell count and platelets; and age. Histology was thought to be a possible factor in patients with early stage squamous cell carcinoma, in as much as the recurrence rate for patients with T1N0 stage disease has been reported to be lower than that of patients with adenocarcinoma when both are treated by surgical resection. Although certain biologic and molecular markers show considerable promise as prognostic factors, it is not yet clear that any of these provides consistent additional information over and above what is available from stage, performance status and weight loss.

The UICC’s publication on prognostic factors divides them into three categories: disease related, patient related and environment related. It further recognises that there may be differences in the prognostic significance of some factors depending on disease extent and type of treatment.

Essential non-small cell lung cancer prognosis factors are:
  • Tumor related
  • Lung cancer stage
  • Hypercalcaemia
  • Superior vena caval obstruction
  • Patient related, such as; health condition
  • Performance status
  • Weight loss
  • Environment related
  • Resection margin (for patients managed surgically)
  • Chemo-radiotherapy for selected Stage III
  • Chemotherapy for selected Stage IV.
Two studies have suggested that experience with administering treatment may also be an important environmental prognostic factor. The survival of patients was superior both for surgery and chemoradiotherapy in institutions with greater experience.

Main Article: Non-small Cell Lung Cancer

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