Asbestos have become part of our life, it is exist among us, and we use it to build our house and many building. Asbestos can cause many types of lung disease, includes lung cancer. There is a synergistic effect between tobacco smoking and asbestos in the formation of lung cancer. In the UK, asbestos accounts for 2–3% of male lung cancer deaths. Asbestos can also cause cancer of the pleura, called mesothelioma (which is often mistaken with lung cancer).
In industrialized country, asbestos exposure is giving 4% to 12% of all lung cancer cases. The death number from asbestos exposure in the UK in 1929 to 1996 was reaching 18,000 for mesothelioma and 1,800 for lung cancer. . In a study of cancer mortality among about 5 100 asbestos factory workers in east London followed for over 30 years since first exposure10, the excess lung cancer to mesothelioma ratio was 1.55:1.
Most asbestos-caused lung cancers are seems has connection with the combined effects of asbestos and tobacco smoke, so that it is necessary to allow for cigarette smoking in comparable reference populations not exposed to asbestos in order to estimate the excess number of asbestos-caused lung cancers. In this respect, the synergy between tobacco smoke and asbestos has been studied more extensively than the analogous synergy between tobacco smoke and other occupational. In different studies the interaction between asbestos and tobacco smoke for lung cancer induction varies from more than additive to supra-multiplicative, but the relationship approximates a multiplicative model for insulation workers.
A long time of asbestos exposure in work place can cause lung cancer. In studies that calculate the time that needed from the first time asbestos exposure to the diagnosis of lung cancer. The result is, it needs about 35 years and 44 years respectively to make asbestos exposure into lung cancer. For workers who using asbestos-containing materials and works for more than 2 years, Nicholson et al* observed a significantly elevated relative risk for lung cancer that occurred within 10 years and thereafter remained constant throughout the period of observation.
* Nicholson WJ, Perkel G, Selikoff IJ, Seidman H. Cancer from occupational asbestos exposure projections 1980–2000. Peto R, Schneiderman M (eds) Quantification of Occupational Cancer. New York: Cold Spring Harbor Laboratory, 1981: 87–111.
Main Article - Lung Cancer Risk Radon Gas
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